| Rolle | Person |
|---|---|
| Elena Fisher | Anke Kortemeier |
| Nathan Drake | Jens Wendland |
| Samuel Drake | Daniel Welbat |
| Victor „Sully“ Sullivan | Richard van Weyden |
| Rolle | Person |
|---|---|
| Cassie Drake | Leyla Trebbien |
| Chloe Frazer im Mehrspieler-Modus | Sabina Godec |
| Hector Alcázar | Aart Veder |
| Jameson | Erik Borner |
| Nadine Ross | Isabella Bartdorff |
| Rafe Adler | Isaak Dentler |
| Samuel Drake (jung) | Lars Waltl |
| Schwester Catherine | Gisa Bergmann |
| Vargas | Dirk Hardegen |
