| Abernathy | Diana Borgwardt |
| Adam Smasher | Reinhard Scheunemann |
| Alena „Alex“ Xenakis im DLC »Phantom Liberty« | Marieke Oeffinger |
| Alt Cunningham | Nicole Hannak |
| Anders Hellman | Jaron Löwenberg |
| Angel | Patrick Keller |
| Arthur Jenkins | Felix Spieß |
| Asa Risu | Uschi Hugo |
| Aurore Cassel im DLC »Phantom Liberty« | Sarah Alles-Shahkarami |
| Aymeric Cassel im DLC »Phantom Liberty« | Michael Baral |
| Barry | Peter Sura |
| Bhikkhu | Klaus Lochthove |
| Bill Jablonsky | Paul Matzke |
| Blue Moon | Jennifer Weiß |
| Boz / 6th Street | Tobias Lelle |
| Brendan | Nico Sablik |
| Bryce Mosley | Björn Landberg |
| Captain Sherman | Nick Forsberg |
| Carol Emeka | Sabine Jaeger |
| Cassidy Righter | Jan Spitzer |
| Cassius Ryder | Harald Effenberg |
| Claire Russell | Dirk Petrick |
| Coach Fred | Marlin Wick |
| Concierge des Konpeki Plaza | Bernd Vollbrecht |
| Crispin Weyland | Daniel Zillmann |
| Delamain | Peter Flechtner |
| Delamain (GLaDOS-Stimme) | Gertrude Thoma |
| Dexter Deshawn | Tilo Schmitz |
| Dino Dinovic | Peter Sura |
| Dorian | Julia Bautz |
| Dum Dum | Matthias Rimpler |
| El Capitan Reyes | Nicolas Buitrago |
| Elizabeth Peralez | Andrea Cleven |
| Evelyn Parker | Magdalena Turba |
| Fingers | Hendrik Martz |
| Gerald Winkler / Garry der Prophet | Joachim Kaps |
| Gillian Jordan | Cornelia Waibel |
| Gottfried | Erik „Gronkh“ Range |
| Groupie | Alice Bauer |
| Haitianischer Söldner | Samuel Zekarias |
| Hanako Arasaka | Alexandra Yoko Hagino |
| Harold Han | Gunnar Helm |
| Iris Tanner | Anja Rybiczka |
| Jackie Welles | Carlos Lobo |
| Jefferson Peralez | Martin Schubach |
| Jeremiah Grayson | Viktor Neumann |
| Joshua | Fabian Oscar Wien |
| Joss | Lara „Loft“ Trautmann |
| Jun Azegami Blitzer | Klaus Lochthove |
| Kaoru Fujioka | Klaus Lochthove |
| Karim | Uve Teschner |
| Karina Lee | Josephine Schmidt |
| Kerry Eurodyne | Charles Rettinghaus |
| Kirk Sawyer | Matthias Rimpler |
| Liam Northton | Fabian Kluckert |
| Lina Malina | Mascha Raykhman |
| Lizzy Wizzy | Jenny Maria Meyer |
| Lucius Rhyne | Sven Brieger |
| Maiko Maeda | Birte Baumgardt |
| Mama Wells | Iris Artajo |
| Maman Brigitte | Dela Dabulamanzi |
| Marcus Ichida | Nick Forsberg |
| Mateo | Sebastian Christoph Jacob |
| Meredith Stout | Sonja Spuhl |
| Miao Zhu (NPC-Bewohner) | Andi Krösing |
| Misty Olszewski | Lina Rabea Mohr |
| Mitch Anderson | Frank Schaff |
| Mox | Lara „Loft“ Trautmann |
| Mr. Hands bis Update 2.0 | Hans-Eckart Eckhardt |
| Mr. Hands ab Update 2.0 | Matthias Klie |
| Nancy Hartley (Bes Isis) | Silvia Mißbach |
| Nathan Osgood | Tobias Lelle |
| NCPD-Funk | Heike Schroetter |
| Nix | Florian Hoffmann |
| Noah / Barkeeper | Stefan Bräuler |
| Ozob Bozo | Ralf David |
| Pastor Colver | Hans Bayer |
| Pepe Najarro | Sebastian Christoph Jacob |
| Petrova | Katharina Spiering |
| Placide | Jan-David Rönfeldt |
| Proxy | Uschi Hugo |
| Rachel Casich | Rieke Werner |
| Regina Jonas | Uschi Hugo |
| Rezeptionistin | Anja Rybiczka |
| Rick | Hans Bayer |
| River Ward | Johannes Berenz |
| Robert Wilson | Hans-Eckart Eckhardt |
| Rogue Amendiares | Martina Treger |
| Rosalind Myers im DLC »Phantom Liberty« | Daniela Hoffmann |
| Royce | Stefan Bräuler |
| Sandayu Oda | Patrick Keller |
| Sandra Dorsett | Rieke Werner |
| Santiago Aldecaldo | Christoph Banken |
| Sasquatch | Katy Karrenbauer |
| Saul Bright | Torsten Michaelis |
| Sebastian „Padre“ Ibarra | Bernd Vollbrecht |
| Sergei Karasinsky | Bernd Egger |
| Skippy | Santiago Ziesmer |
| Song Mo Mi („Songbird“) im DLC »Phantom Liberty« | Julia Kaufmann |
| Spider Murphy | Ronja Peters |
| Stanley Media | Till Hagen |
| Stefan | Dennis Sandmann |
| Steve | Linus Drews |
| Steves Vater | Viktor Neumann |
| Stints | Armin Schlagwein |
| T-Bug | Ann Vielhaben |
| Theo | Anissa „Anni The Duck“ Baddour |
| Tom | Paul Matzke |
| Towiq Iqbal | Ricardo Richter |
| TV-Sport-Kommentator | Hans Georg „Hansi“ Küpper |
| Valentino in Bar 1 | Sebastian Christoph Jacob |
| Valentino in Bar 2 | Christoph Banken |
| Vance Noren | Andi Krösing |
| Viktor Vektor | Mario Hassert |
| Voodoo Boy | Daniel Kröhnert |
| Voodoo Boys-Gangmitglied | Samuel Zekarias |
| Wakako Okada | Judith Steinhäuser |
| Weldon Holt | Felix Spieß |
| Werbesprecher Capitan Caliente | Michael Pan |
| Werbesprecher Mr. Stud | Florian Clyde |
| Werbesprecherin Arasaka | Melinda Rachfahl |
| Werbesprecherin Chrome Manticore | Daniela Molina |
| Werbesprecherin Lizzies | Lara „Loft“ Trautmann |
| Woodman | Dirc Simpson |
| Yorinobu Arasaka | Yusuke Yamasaki |
| Ziggy Q | Dirk Petrick |
