| Charakter | Person |
|---|---|
| Goro Takemura | Tōru Tanabe |
| Johnny Silverhand | Benjamin Völz |
| Judy Alvarez | Kristina Tietz |
| Kurt Hansen im DLC »Phantom Liberty« | Torben Liebrecht |
| Panam Palmer | Giovanna Winterfeldt |
| Reed im DLC »Phantom Liberty« | Oliver Stritzel |
| V (Männlich) | Björn Schalla |
| V (Weiblich) | Flavia Vinzens |
| Charakter | Person |
|---|---|
| Alt Cunningham | Nicole Hannak |
| Anders Hellman | Jaron Löwenberg |
| Claire Russell | Dirk Petrick |
| Delamain | Peter Flechtner |
| Delamain (GLaDOS-Stimme) | Gertrude Thoma |
| Dexter Deshawn | Tilo Schmitz |
| Dorian | Julia Bautz |
| Evelyn Parker | Magdalena Turba |
| Gottfried | Erik „Gronkh“ Range |
| Hanako Arasaka | Alexandra Yoko Hagino |
| Jackie Welles | Carlos Lobo |
| Kerry Eurodyne | Charles Rettinghaus |
| Lina Malina | Mascha Raykhman |
| Maiko Maeda | Birte Baumgardt |
| Maman Brigitte | Dela Dabulamanzi |
| Misty Olszewski | Lina Rabea Mohr |
| Mitch Anderson | Frank Schaff |
| Ozob Bozo | Ralf David |
| Placide | Jan-David Rönfeldt |
| Rachel | Rieke Werner |
| River Ward | Johannes Berenz |
| Rogue Amendiares | Martina Treger |
| Sandayu Oda | Patrick Keller |
| Saul Bright | Torsten Michaelis |
| Skippy | Santiago Ziesmer |
| Stanley Media | Till Hagen |
| T-Bug | Ann Vielhaben |
| TV-Sport-Kommentator | Hans Georg „Hansi“ Küpper |
| Viktor Vektor | Mario Hassert |
| Yorinobu Arasaka | Yusuke Yamasaki |
